Creep: An unknown toxic, highly corrosive sludge called the creep comes out of nowhere and decimates almost every race and world in the galaxy. One city remains, keeping the creep at bay with its anti creep arsenal, surrounding the city. The city holds 1 million citizens. Rebellions or wars sometimes take place within the city, some even utlize the creep as a weapon, shutting down anti creep weapons to a city district. Abominations may be created, beasts with no purpose but to destroy life, blah blah blah you get the idea.
Flooded World: Earth, or another planet, gets flooded with water somehow, form melting ice or a massive comet that melted or something. All life remains underwater, relying on life support, submarines, etc.... They can be cut off from civilization on other worlds, or be all that is left.
Zombies: You all know. Zombies take over the world, and they are their mutations rule. The several thousand remaining survivors have wars over what food and water and weapons remain. Survival is difficult, you get the idea.
Nuclear Apocalypse: You get the idea.
Ice Age: Uber uber ice age. Like, the atmosphere to a world gets several holes in it or something, and temperatures are half as cold as space. (-150 degrees fahrenheit or something)
Torn apart world: A world literally gets torn to pieces, and turns into something of an asteroid field, with what pieces of the planet are left connected by artificial means, all still contained in an atmosphere(s).
You get the idea.
Post your own if you want, and give me some feedback on my ideas.